Cancer Cure Now
Hyperthermia
Hyperthermia Exposes Tissues To High Temperatures
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Hyperthermia, also called thermal therapy, involves exposing tissues to high temperatures, up to 113 degrees Fahrenheit (42 degrees C). This damages and kills cancer cells, with minimal damage to normal tissues, which produce proteins to mitigate heat injury and can tolerate temperatures up to 111 degrees. Also, tumors have poor blood supply relative to their metabolic needs and cannot dissipate heat, so they tend to get hotter than the surrounding area. Hyperthermia is almost always used in conjunction with other treatments, and can be given just before chemo or radiotherapy in order to enhance the effects. Normally, part of the damage caused by radiation is repaired by the cancer cells, enabling some to survive; however, heat interferes with this repair mechanism. Hyperthermia is now approved in the U.S. for treatment of breast cancer recurrence. Hyperthermia can be applied to the entire body, or just one area. Diarhhea, nausea and vomiting are common side effects of whole-body hyperthermia, which involves induction of a fever up to 107-108 degrees Fahrenheit. The National Institute Of Health reports several ongoing clinical trials in the United States on the effectiveness of hyperthermia. Numerous studies have been done on hyperthermia in combination with radio or chemotherapy for the treatment of various types of cancer. 1,2,3,4,5,6,7,8 Many of these studies have shown a significant reduction in tumor size. 1,3,6,7 However, patient survival was not always increased. 3,5,7 History For hundreds of years, heat has been used as a medical treatment for a variety of illnesses. Examples include the traditional Finnish sauna and Native American sweat lodges. Historically, doctors have noticed that "spontaneous remissions" of tumors often occurred after a serious febrile illness. In the West Indies, natives afflicted with syphilis or cancer deliberately subjected themselves to infection from such high fever diseases as malaria, typhus fever or typhoid fever. In biological clinics in Europe, artificially induced fever, usually in the form of overheating baths, has been used successfully to treat a variety of conditions including cancer. Dr. Josef Issels, the founder of the renowned Issels Clinic in Germany, has said, "Artificially induced fever has the greatest potential in the treatment of many diseases, including cancer." The Issels Clinic currently uses hyperthermia as part of a combination treatment for cancer. ------------------------------------------------------------------------------------------------------------------------------------------------------------------ (1). Van der Zee J. Heating the patient: A promising approach? Annals of Oncology 2002; 13:1173-1184 (2). Hildebrandt B, Wust P, Ahlers O et all The Cellular and Molecular Basis of Hyperthermia Critical Reviews in Oncology/Hematology 2002; 43:33-56 (3). Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. The Lancet Oncology 2002; 3:487-497. (4). Alexander HR. Isolation perfusion. In: DeVita VT Jr., Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. Vol. 1 and 2. 6th ed. Philadelphia: Lippincott Williams and Wilkins, 2001. (5). Falk MH, Issels RD Hyperthermia in Oncology International Journal of Hyperthermia 2001; 17(1):1-18 (6). Dewhirst MW, Gibbs FA Jr, Roemer RB, Samulski TV. Hyperthermia. In: Gunderson LL, Tepper JE, editors. Clinical Radiation Oncology. 1st ed. New York, NY: Churchill Livingstone, 2000. (7). Kapp DS, Hahn GM, Carlson RW. Principles of Hyperthermia. In: Bast RC Jr., Kufe DW, Pollock RE, et al., editors. Cancer Medicine e.5. 5th ed. Hamilton, Ontario: B.C. Decker Inc., 2000. (8). Feldman AL Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy Journal of Clinical Oncology 2003 21(24):4560-456 |
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